Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease
- 作者：Ayla Ozturk ; Steven T. DeKosky and M. Ilyas Kamboh
- 关键词：Genetics ; Polymorphisms ; Chromosome 10
- 刊名：Neuroscience Letters
- 出版年：2006
- 期刊代码：52_03043940
- 类别：neu
- 出版时间：9 October 2006
- 卷：406
- 期：3
- 页码：265-269
- 文件大小：106 K
摘要
Insulin-degrading enzyme (IDE) is a strong biological and positional candidate gene for Alzheimer's disease (AD). Previously some studies have examined the role of common variation in the IDE gene with AD risk but the results have been inconsistent. In this study we examined the role of 5 SNPs that define a linkage disequilibrium (LD) block spanning 276 kb around IDE. Our sample comprised up to 1012 late-onset AD (LOAD) cases and 771 older white controls. In addition, we also examined the association of these SNPs with quantitative measures of AD progression, namely age-at-onset (AAO), disease duration and Mini-Mental State Examination (MMSE) score. None of the SNPs examined in this fairly large case-control sample revealed significant association with AD risk. These SNPs also showed no significant association with AD quantitative traits.