No association of SORL1 SNPs with Alzheimer's disease

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• 作者：Ryan L. Minster ; Steven T. DeKosky ; M. Ilyas Kamboh
• 关键词：Alzheimer's disease ; SORL1 ; Genetics
• 刊名：Neuroscience Letters
• 出版年：2008
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：1 August 2008
• 卷：440
• 期：2
• 页码：190-192
• 文件大小：120 K

摘要

SORL1 is an element of the amyloid precursor protein processing pathway and is therefore a good candidate for affecting Alzheimer's disease (AD) risk. Indeed, there have been reports of associations between variation in SORL1 and AD risk. We examined six statistically significant single-nucleotide polymorphisms from the initial observation in a large Caucasian American case–controls cohort (1000 late-onset AD [LOAD] cases and 1000 older controls). Analysis of allele, genotype and haplotype frequencies revealed no association with LOAD risk in our cohort.