Guided delivery of adeno-associated viral vectors into the primate brain

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• 作者：Ernesto A. Salegio ; Lluis Samaranch ; Adrian P. Kells ; John Forsayeth ; Krystof Bankiewicz ; ^{Krystof.Bankiewicz@ucsf.edu}
• 关键词：Gene delivery ; AAV ; Non-human primate ; MRI-guided delivery ; Thalamus ; Basal ganglia
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2012
• 期刊代码：2_0169409x
• 类别：bio
• 出版时间：15 May, 2012
• 卷：64
• 期：7
• 页码：598-604
• 文件大小：897 K

摘要

In this review, we discuss recent developments in the delivery of adeno-associated virus-based vectors (AAV), particularly with respect to the role of axonal transport in vector distribution in the brain. The use of MRI-guidance and new stereotactic aiming devices have now established a strong foundation for neurological gene therapy to become an accepted procedure in interventional neurology.