- 作者：Damien C. Weber ; Annie W. Chan ; Simmons Lessell ; James F. McIntyre ; Saveli I. Goldberg ; Marc R. Bussiere ; Markus M. Fitzek ; Allan F. Thornton ; Thomas F. DeLaney
- 关键词：Paranasal sinus cancer ; Proton beam radiation therapy ; Accelerated fractionated radiation ; Late visual complications
- 刊名：Radiotherapy and Oncology
- 出版年：2006
- 期刊代码：231_01678140
- 类别：med
- 出版时间：December 2006
- 卷：81
- 期：3
- 页码：243-249
- 文件大小：101 K
To investigate the visual outcomes of patients with advanced sinonasal malignancies treated with proton/photon accelerated fractionated radiation (AFR).
Patients and methods
Between 1991 and 2001, AFR was used to treat 36 patients with advanced stage primary (n = 33) or recurrent (n = 3) nasal or paranasal malignant tumors. Full ophthalmologic follow-up was documented. The median dose to the gross tumor volume (GTV) was 69.6 CGE (range 60.8–77). Visual complications were graded according to the National Cancer Institute Common Toxicity Criteria (CTC) and the late effects of normal tissue (LENT) scoring systems. The median follow-up was 52.4 months (range 17–122.8).
Results
Thirteen patients developed late visual/ocular toxicity. Cataracts were LENT grade 1 and 3 in 2 patients and 1 patient, respectively. One LENT grade 1 vascular retinopathy and 1 optic neuropathy were also observed. Three and five patients presented with nasolacrimal duct stenosis (CTC grade 2, 2 patients; CTC grade 3, 1 patient) and dry-eye syndrome (CTC grade 1, 1 patient; CTC grade 2, 4 patients), respectively. The 3- and 5-year probability of LENT/CTC grade 2 visual toxicity were 15.8 ± 6.7%and 20.7 ± 7.8%, respectively.
Conclusions
AFR for locally advanced nasal cavity and paranasal sinus tumors enables delivery of 70 CGE to the tumor with acceptable ophthalmologic complications.