Behavioral effects of oral subacute exposure to BDE-209 in young adult mice: A preliminary study

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• 作者：Luis Heredia^a ; ^b ; Margarita Torrente^a ; ^b ; ^{margarita.torrente@urv.cat} ; Marí ; a T. Colomina^a ; ^b ; José ; L. Domingo^b
• 关键词：BDE-209 ; Tg2576 mice ; Anxiety ; Spatial learning ; Subacute exposure
• 刊名：Food and Chemical Toxicology
• 出版年：2012
• 期刊代码：20_02786915
• 类别：pha
• 出版时间：March-April, 2012
• 卷：50
• 期：3-4
• 页码：707-712
• 文件大小：342 K

摘要

In this study, we examined the effects of an oral subacute exposure to 2,2鈥?3,3鈥?4,4鈥?5,5鈥?6,6鈥?decabromodiphenyl ether (BDE-209) on young adult inbred wild type Tg2576 mice. BDE-209 was administered by gavage at doses of 0 and 20 mg/kg/day dissolved in sunflower oil for 15 days. Two behavioral endpoints were examined: anxiety-activity in a light/dark test and a zero maze test, and learning and spatial memory in a water maze test. Young adult mice exposed to BDE-209 showed a reduction in anxiety levels and a delayed learning in a spatial memory task. Although the results indicated that behavioral effects were present in a young adult exposed population of wild type Tg2576 mice, further studies on chronic exposure to BDE-209 are clearly necessary in order to corroborate these effects.