Mapping of a new target region of allelic loss at 21q22 in primary gastric cancers

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• 作者：Park ; Won Sang ; Oh ; Ro Ra ; Park ; Jik Young ; Yoo ; Nam Jin ; Lee ; Sug Hyung ; Shin ; Min Sun ; Kim ; Su Young ; et. al.
• 关键词：Gastric cancer ; Loss of heterozygosity ; 21q22
• 刊名：Cancer Letters
• 出版年：2000
• 期刊代码：44_03043835
• 类别：med
• 出版时间：October 16, 2000
• 卷：159
• 期：1
• 页码：15-21
• 文件大小：485 K

摘要

To determine the minimal region of deletion on 21q22 in gastric cancer, we performed a high-density loss of heterozygosity (LOH) study with eight polymorphic microsatellite markers. Among the 43 tumors examined, 20 (50%) of 40 informative carcinomas showed LOH at one or more loci. The peak LOH frequency was identified at D21S1820 (34.2%) in 21q22.3. This data suggests that this locus might harbor a new tumor suppressor gene in an area <0.332 Mb in physical map distance defined by D21S1820 and D21S49. Thus, we speculate that trefoil factor family 1 (TFF1), located in this narrow region, might be the most probable candidate gene involved in gastric cancer carcinogenesis.