To search for additional amplification and
deletion sites that may serve as a starting point for the discovery of new oncogenes or tumor suppressor genes, 30 Japanese localized prostate cancers were analyzed by comparative genomic hybridization (CGH) in this study. CGH was used to search for changes in DNA sequence copy-number in a series of 30 primary prostate adenocarcinomas, consisting of 22 cases of pT2N0 (organ confined; without capsular invasion) and 8 cases of pT3N0 (with capsular invasion), removed by radical prostatectomy. CGH revealed that the shortest regions of overlap (SRO) of gains in pT2N0 were at 8q22.2
![not, vert, similar](http://www.sciencedirect.com/scidirimg/entities/223c.gif)
q24.2,
11q
13.
1![not, vert, similar](http://www.sciencedirect.com/scidirimg/entities/223c.gif)
q
14.
1, and
12q23![not, vert, similar](http://www.sciencedirect.com/scidirimg/entities/223c.gif)
q24.2, whereas the SRO of losses were seen at 8p23.3
![not, vert, similar](http://www.sciencedirect.com/scidirimg/entities/223c.gif)
p22,
13q2
1.2
![not, vert, similar](http://www.sciencedirect.com/scidirimg/entities/223c.gif)
p22, and
18q2
1![not, vert, similar](http://www.sciencedirect.com/scidirimg/entities/223c.gif)
q22. The SRO of gains in pT3N0 were noted at 5q32
![not, vert, similar](http://www.sciencedirect.com/scidirimg/entities/223c.gif)
q34, 8q22.3
![not, vert, similar](http://www.sciencedirect.com/scidirimg/entities/223c.gif)
q24.
1,
11q
14.
1![not, vert, similar](http://www.sciencedirect.com/scidirimg/entities/223c.gif)
q22.3, and
12q22
![not, vert, similar](http://www.sciencedirect.com/scidirimg/entities/223c.gif)
q24.2, whereas the SRO of losses were seen at
18q2
1.2
q23. These results suggest that gains or losses of DNA in these regions are important for prostate cancer progression. The detection of the SRO may serve as a starting point to discover novel oncogenes and tumor suppressor genes involved in prostate cancer progression.