• 作者：O. Delgado ; M. Guerra ; E. Reyna ; ^{sippenbauch@gmail.com} ; D. Torres ; M. Colmenares ; J. Santos ; J. Mejí ; a ; N. Reyna
• 关键词：Lí ; pidos ; Lipoproteí ; na (a) ; Menopausia ; Tibolona
• 刊名：Cl铆nica e Investigaci贸n en Ginecolog铆a y Obstetricia
• 出版年：2011
• 期刊代码：pca89_0210573X
• 类别：med
• 出版时间：January-February 2011
• 卷：38
• 期：1
• 页码：15-19
• 文件大小：117 K

Objective

To determine modifications in lipids and lipoprotein (a) in postmenopausal women receiving tibolone.

Materials and methods

A sample of 45 postmenopausal women who were treated with a dose of 2.5 mg of tibolone daily for 6 months was selected. Serum concentrations of cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), lipoprotein (a) and the cholesterol/HDL and triglyceride/HDL ratios were measured.

Results

Cholesterol, triglyceride, LDL-C and lipoprotein (a) concentrations were significantly reduced after 6 months of tibolone use compared with initial concentrations (p<0.05). A statistically significant decrease in HDL-C was observed (p<0.05). The triglyceride/HDL ratio showed a significant reduction of more than 30%(p<0.05). No significant differences in mean cholesterol/HDL ratio values before and after treatment (p=ns) were found.

Conclusions

Tibolone significantly reduced cholesterol, triglyceride, HDL-C, LDL-C and lipoprotein (a) concentrations and significant modifications in the triglyceride/HDL-C ratio after 6 months of use.