Smart medication through combination of synthetic biology and cell microencapsulation

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• 作者：Simon Auslä ; nder¹ ; Markus Wieland¹ ; Martin Fussenegger ; ^{fussenegger@bsse.ethz.ch}
• 关键词：Synthetic Biology ; Cell Implants ; Encapsulation ; Synthetic Gene Networks
• 刊名：Metabolic Engineering
• 出版年：2012
• 期刊代码：98_10967176
• 类别：ce
• 出版时间：May, 2012
• 卷：14
• 期：3
• 页码：252-260
• 文件大小：958 K

摘要

Recent advances in the field of synthetic biology have led to the design of a new generation of complex, man-made biological networks that operate inside living cells in a desired manner. Key elements of these systems are often controllable genetic switches that are capable of processing therapeutic signals by sensing and responding to the environment. For biomedical applications, however, it is necessary to seal these engineered cells in order to protect them from the host immune system and enable straightforward removal after completion of the therapy. A promising and successful approach is the microencapsulation of defined cells into a semi-permeable and biocompatible microcapsule. Shielding from the external environment still allows exchange to occur on a molecular basis. Thus, the powerful combination of synthetic biology and microencapsulation has been opening the door to novel and innovative cell-based biomedical applications, such as smart implantable drug delivery systems. This review highlights recent developments in the overlap of these two areas, thereby presenting promising developments and perspectives for future treatment strategies.