Synthesis and biological evaluation of novel steroid-modified ether phospholipids
- 作者：Haralabos C. Karantonis ; Emmanuel N. Pitsinos ; Smaragdi Antonopoulou ; Elias A. Couladouros and Constantinos A. Demopoulos
- 关键词：Steroid ether phospolipids ; Platelets ; Platelet activating factor ; PAF-acetylhydrolase ; Periodontal disease
- 刊名：Chemistry and Physics of Lipids
- 出版年：2005
- 期刊代码：44_00093084
- 类别：bio
- 出版时间：2005
- 卷：138
- 期：1-2
- 页码：12-19
- 文件大小：171 K
摘要
Platelet activating factor is one of the most potent inflammatory ether phospholipid mediators known and structurally modified analogues are of considerable interest as potential therapeutic preparations. Inspired by the proposed structure for a novel endogenous hydroxy-PAF analogue isolated recently from gingival crevicular fluid, we designed and prepared two novel steroid-modified ether phospholipids. These two novel compounds exhibit marked chemical and biological similarities to their endogenous prototype and they antagonize it being less active in inducing washed platelet aggregation through PAF receptors.