Plasma appearance of unesterified astaxanthin geometrical E/Z and optical R/S isomers in men given single doses of a mixture of optical 3 and 3′R/S isomers of astaxanthin fatty acyl diesters

详细信息	查看全文 | 推荐本文 |

• 作者：Coral-Hinostroza ; Gladis N. ; Ytrest脙脙yl ; Trine ; Ruyter ; Bente ; Bjerkeng ; Bj脙脙rn
• 关键词：HDL ; high density lipoproteins ; LDL ; low denisty lipoproteins ; PP ; plasma proteins ; R_T ; HPLC retention time ; TLC ; thin-layer chromatography ; VLDL/CM ; very low density lipoproteins and chylomicrons ; Absorption ; Astaxanthin diesters ; Astax
• 刊名：Comparative Biochemistry and Physiology ; Part C
• 出版年：2004
• 期刊代码：8_15320456
• 类别：pha
• 出版时间：October, 2004
• 卷：139
• 期：1-3
• 页码：99-110
• 文件大小：328 K

摘要

Appearance, pharmacokinetics and distribution of astaxanthin all-E-, 9Z- and 13Z-geometrical and (3R,3芒芒芒R)-, (3R,3芒芒芒S)- and (3S,3芒芒芒S)-optical isomers in plasma fractions were studied in three middle-aged male volunteers (41芒芒芒50 years) after ingestion of a single meal containing first a 10-mg dose equivalent of astaxanthin from astaxanthin diesters, followed by a dose of 100 mg astaxanthin equivalents after 4 weeks. Direct resolution of geometrical isomers and optical isomers of astaxanthin dicamphanates by HPLC after saponification showed that the astaxanthin consisted of 95.2%all-E-, 1.2%9Z- and 3.6%13Z-astaxanthin, of (3R,3芒芒芒R)-, (3R,3芒芒芒S; meso)- and (3S,3芒芒芒S)-astaxanthin in a 31:49:20 ratio. The plasma astaxanthin concentration芒芒芒time curves were measured during 76 h. Astaxanthin esters were not detected in plasma. Maximum levels of astaxanthin (C_max