Sensitization of 5-bromouridine by slow electrons

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• 作者：Abdoul-Carime ; Hassan ; Lim脙脙o-Vieira ; Paulo ; Gohlke ; Sascha ; Petrushko ; Irina ; Mason ; Nigel J. ; et. al.
• 刊名：Chemical Physics Letters
• 出版年：2004
• 期刊代码：7_00092614
• 类别：ph
• 出版时间：August 1, 2004
• 卷：393
• 期：4-6
• 页码：442-447
• 文件大小：287 K

摘要

Substitution of thymidine by 5-bromouridine within DNA sensitizes the nucleic acid to radiation. We show here the ability of low-energy (<12 eV) electrons, abundantly produced along the ionization tracks, to effectively decompose the radiosensitizer via two main fragmentation channels to produce the bromine anion and the 5-bromouracil-yl anion, with a cross-section of 2脙脙10^脙脙脙14 and 9脙脙10^脙脙脙16 cm², respectively. The formation of these negative fragments is accompanied by their corresponding reactive radicals, i.e., uracil-yl radical bound to the sugar moiety and 2-deoxyribose-yl radical, which are both considered as precursors for DNA strand breaks.