Cell cycle control by anchorage signaling

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• 作者：Hiroto Okayama ; ^{okayama@m.u-tokyo.ac.jp} ; ^{okayama-tky@umin.net}
• 关键词：MCM ; minichromosome maintenance ; preRC ; prereplicative complex ; CAK ; cyclin-dependent kinase-activating kinase ; CKI ; cyclin-dependent kinase inhibitor ; ECM ; extracellular matrix ; mTORC1 ; mammalian target of rapamycin complex 1 ; mTORC2 ; mammalian target of
• 刊名：Cellular Signalling
• 出版年：2012
• 期刊代码：42_08986568
• 类别：bio
• 出版时间：August, 2012
• 卷：24
• 期：8
• 页码：1599-1609
• 文件大小：891 K

摘要

Virtually all the cells constituting solid organs in adult animals require anchorage to the extracellular matrix for their proliferation and survival. When deprived of anchorage, those cells arrest in G₁ phase of the cell cycle and die of apoptosis known as anoikis. However, if malignantly transformed, cells no longer require such an anchorage to proliferate and survive, and it is generally thought that the acquirement of this ability underlies the tumorigenic and metastatic capability of malignant cells. Therefore, for the past two decades, great efforts have been devoted to uncovering the nature of the anchorage signal and the mechanism by which this signal controls the G₁-S transition in the cell cycle with little progress. However, several critical findings were recently made on anchorage signaling and the control of the cell cycle and cell death by this signaling. This review focuses on the newly emerging understanding and perspective of this highly important cell cycle and cell death regulation.