WDR1 presence in the songbird basilar papilla
- 作者：Henry J. Adler ; Elena Sanovich ; Elizabeth F. Brittan-Powell ; Kai Yan ; Robert J. Dooling
- 关键词：RT– ; PCR ; Immunocytochemistry ; Confocal microscopy ; Belgian Waterslager canary ; Hearing ; Acoustic trauma ; Genetic hearing loss
- 刊名：Hearing Research
- 出版年：2008
- 期刊代码：111_03785955
- 类别：med
- 出版时间：June 2008
- 卷：240
- 期：1-2
- 页码：102-111
- 文件大小：1208 K
摘要
WD40 repeat 1 protein (WDR1) was first reported in the acoustically injured chicken inner ear, and bioinformatics revealed that WDR1 has numerous WD40 repeats, important for protein–protein interactions. It has significant homology to actin interacting protein 1 (Aip1) in several lower species such as yeast, roundworm, fruitfly and frog. Several studies have shown that Aip1 binds cofilin/actin depolymerizing factor, and that these interactions are pivotal for actin disassembly via actin filament severing and actin monomer capping. However, the role of WDR1 in auditory function has yet to be determined.