L’exercice de la médecine au sein d’un établissement de santé privé : quelles responsabilités ?
- 作者：Mireille Bacache
- 关键词：Drosophila ; Twinstar ; Cofilin ; Actin depolymerizing factor ; Rhabdomere ; Eye
- 刊名：Medecine et Droit
- 出版年：2008
- 期刊代码：194_12467391
- 类别：med
- 出版时间：March-April 2008
- 卷：2008
- 期：89
- 页码：48-52
- 文件大小：120 K
摘要
Drosophila photoreceptors undergo marked changes in their morphology during pupal development. These changes include a five-fold elongation of the retinal cell body and the morphogenesis of the rhabdomere, the light sensing structure of the cell. Here we show that twinstar (tsr), which encodes Drosophila cofilin/ADF (actin-depolymerizing factor), is required for both of these processes. In tsr mutants, the retina is shorter than normal, the result of a lack of retinal elongation. In addition, in a strong tsr mutant, the rhabdomere structure is disorganized and the microvilli are short and occasionally unraveled. In an intermediate tsr mutant, the rhabdomeres are not disorganized but have a wider than normal structure. The adherens junctions connecting photoreceptor cells to each other are also found to be wider than normal. We propose, and provide data supporting, that these wide rhabdomeres and adherens junctions are secondary events caused by the inhibition of retinal elongation. These results provide insight into the functions of the actin cytoskeleton during morphogenesis of the Drosophila eye.