Defective sterol Δ⁵⁽⁶⁾ desaturase as a cause of azole resistance in Ustilago maydis

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• 作者：Joseph-Horne ; Timothy ; Manning ; Nigel J. ; Hollomon ; Derek ; Kelly ; Steven L.
• 关键词：Azole ; Resistance ; P450 ; Sterol desaturase ; Ustilago maydis
• 刊名：FEMS Microbiology Letters
• 出版年：1995
• 期刊代码：34_03781097
• 类别：imm
• 出版时间：March 15, 1995
• 卷：127
• 期：1-2
• 页码：29-34
• 文件大小：358 K

摘要

Resistance to azole antifungals in Ustilago maydis was associated with a leaky defect in sterol Δ⁵⁽⁶⁾ desaturase. This defect resulted in reduced accumulation of 14α-methylergosta-24(28)-diene-3β,6α-diol and an increase in the proportion of 14α-methylfecosterol in treated cells when compared to the parent strain. The results demonstrate the importance of this mechanism in pathogenic fungi.