Evaluation of the amine derivatives of Monascus pigment with anti-obesity activities

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• 作者：Deokyeong Choe¹ ; Juyeon Lee¹ ; Soohyun Woo¹ ; Chul Soo Shin ; ^{csshin@yonsei.ac.kr}
• 关键词：Fungal pigment ; Monascus fermentation ; Amine derivatives ; Anti-obesity
• 刊名：Food Chemistry
• 出版年：2012
• 期刊代码：48_03088146
• 类别：abs
• 出版时间：1 September, 2012
• 卷：134
• 期：1
• 页码：315-323
• 文件大小：1287 K

摘要

Forty-seven amine derivatives of Monascus pigment were produced via a series of fermentation and chemical derivation. Their anti-obesity activities were determined using cellular and mice tests. Among the derivatives, 16 derivatives showed an inhibitory activity against adipogenic differentiation in 3T3-L1 cells. Both the number and droplet size of fatty cells was reduced by treatment with the inhibitory derivatives. The derivatives of 4-phenylbutylamine (PBA) (2.5 渭M) and 2-(p-toyly) ethylamine (TEA) (12.5 渭M) caused approximately 40%inhibition. The transcription factors PPAR纬 and C/EBP伪 were down-regulated by the PBA derivative and the TEA derivative at 10 渭M. When a high fat diet (HFD) supplemented with either 0.1 mg PBA derivative/g-mouse/day (PBA 0.1) or 0.4 mg TEA derivative/g-mouse/day (TEA 0.4) was fed to C57BL/6 mice, weight gain was reduced by 47.7%and 59.5%, respectively, compared to the HFD group. The smallest epididymal adipose tissue (EAT) size was obtained for the TEA 0.2 (HFD supplemented with 0.2 mg TEA/g-mouse/day) group and confirmed by micro-CT images. Supplementation of TEA derivative reduced the total cholesterol content in mice serum, especially LDL. Thus, HTR values increased and AI values decreased, indicating that the supplement has an anti-obesity effect.