The ocular forms and those with large vein involvement, require a minimal attack treatment with 1mg/kg/d of prednisone. Cortisone assaults are often prescribed despite the fact that their efficacy remains to be demonstrated. Curative treatment with heparin (calcic or of low molecular weight) should be prescribed for 5 to 7 days with later relay to a platelet anti-aggregant, without any randomised study having validated this proposition.
The iatrogenic risk of corticosteroids is high and alternative treatments should be proposed: azathioprine, methotrexate, dapsone or hydroxychloroquine. Osteoporosis is the most frequent complication of corticosteroid therapy and must be avoided by the administration of a biphosphonate.
La Presse Médicale, Volume 33, Issue 1, January 2004, Pages 41-50 Christian Agard, Jacques Henri Barrier Abstract class="mlktScroll"> class="h3">Résuméclass="h4">D’une manière généraleLes corticoïdes restent la base du traitement de la maladie de Horton et la prednisone est la molécule de choix. Ils permettent une amélioration des symptômes et diminuent considérablement le risque de cécité. Plusieurs formes cliniques de la maladie doivent être individualisées afin de préciser pour chacune d’entre elles les modalités de la corticothérapie et les traitements éventuels à associer. |
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