Development of biodegradable scaffolds based on magnetically guided assembly of magnetic sugar particles

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• 作者：Chengzhi Hu^a ; ^{huchengz@gmail.com} ; ^{huchengz@robo.mein.naogya-u.ac.jp} ; Tomoyuki Uchida^a ; Carlos Tercero^a ; Seiichi Ikeda^a ; Katsutoshi Ooe^a ; Toshio Fukuda^a ; Fumihito Arai^b ; Makoto Negoro^c ; Guiryong Kwon^d
• 关键词：Magnetic sugar particles ; Vascular scaffold ; Magnetic manipulation ; Biodegradable scaffold ; Tissue engineering
• 刊名：Journal of Biotechnology
• 出版年：2012
• 期刊代码：53_01681656
• 类别：imm
• 出版时间：31 May, 2012
• 卷：159
• 期：1-2
• 页码：90-98
• 文件大小：1957 K

摘要

Biodegradable scaffolds with controlled pore layout and porosity have great significance in tissue engineering for cell penetration, tissue ingrowth, vascularization, and nutrient delivery. Porogen leaching has been commonly used to control pore size, pore structure and porosity in the scaffold. In this paper we focus on the use/development of two magnetically guided porogen assembly methods using magnetic sugar particles (MSPs) for scaffold fabrication. First, a patterning device is utilized to align MSPs following designed templates. Then a magnetic sheet film is fabricated by mixing poly(vinyl alcohol, PVA) and NdFeB powder for steering the MSPs. After poly(l-lactide-co-蓻-caprolactone) (PLCL) casting and removal of the sugar template, a scaffold with spherical pores is obtained. The surface and the inner structure of the scaffolds are evaluated using light and electron micrographs showing their interconnection of pores, pore wall morphology and porosity. Single layer scaffolds with the size of 8 mm in width and 10 mm in length were constructed with controllable pore diameters in the ranges of 105-150 渭m, 250-300 渭m and 425-500 渭m.