Long-term survival (>10 years) of patients >60 years with induction therapy after cardiac transplantation
- 作者：Zuckermann ; Andreas ; Dunkler ; Daniela ; Deviatko ; Elena ; Bodhjalian ; Arthur ; Czerny ; Martin ; et. al.
- 关键词：Cardiac transplantation ; Age ; Risk factors ; Survival ; Antibody induction therapy
- 刊名：European Journal of Cardio-Thoracic Surgery
- 出版年：2003
- 期刊代码：89_10107940
- 类别：med
- 出版时间：August, 2003
- 卷：24
- 期：2
- 页码：283-291
- 文件大小：728 K
摘要
Objective: Cardiac transplantation has become an established method for end-stage heart disease. Short- and mid-term outcome has been known to be similar between younger and older (>60 years) recipients. So far, nothing is known about long-term outcome of old patients and the potential long-term effects of antibody induction therapy in these patients. The purpose of this study was to analyse long-term outcome of old cardiac transplant recipients who underwent antibody induction therapy. Methods: Since 1989, 203 patients (total n=882) above 60 years have been transplanted at our center. On these patients n=66 were above 65 years. Survival, incidences of rejection, infection, cancer, graft arteriosclerosis and the amount of renal insufficiency were compared with patients <60 years (n=679), transplanted during the same period of time. Freedom from specific event was computed by Kaplan–Meier analysis and compared by log–rank test. Results: Ten year survival was similar in all groups (<60 years: 53.7%; 60–64 years: 53.1%and >65 years: 60.2%; P