Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone

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• 作者：Reuben Antony^a ; Xia Sheng^b ; Ehsan A. Ehsanipour^b ; Emily Ng^b ; Rocky Pramanik^b ; Lars Klemm^c ; ^d ; Brian Ichihara^b ; Steven D. Mittelman^b ; ^c ; ^d ; ^e ; ^{smittelman@chla.usc.edu}
• 关键词：Vitamin D ; Calcitriol ; Acute lymphoblastic leukemia ; Dexamethasone
• 刊名：Leukemia Research
• 出版年：2012
• 期刊代码：186_01452126
• 类别：med
• 出版时间：May, 2012
• 卷：36
• 期：5
• 页码：591-593
• 文件大小：397 K

摘要

Vitamin D deficiency has been linked with increased cancer risk, and vitamin D has been shown to be cytotoxic to some cancer cells in vitro. In the present study we evaluated whether vitamin D would have antiproliferative or cytotoxic effects on human pre-B acute lymphoblastic leukemia cells. Contrary to our hypotheses, calcitriol, the active form of vitamin D, had no effect on leukemia cell proliferation. Calcitriol actually had a modest effect to impair dexamethasone cytotoxicity and induction of apoptosis. Further studies are needed to evaluate the effects of vitamin D on leukemia cells in vivo.