Synthesis and biological activities of novel dialkyl (4-trifluoromethylphenylamino)-(4-trifluoromethyl or 3-fluorophenyl) methylphosphonates

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• 作者：Guoping Zhang ; Baoan Song ; Wei Xue ; Linhong Jin ; Deyu Hu ; Qiongqiong Wan ; Ping Lu ; Hua Wang ; Song Yang ; Qianzhu Li and Gang Liu
• 关键词：Aminoalkylphosphonates ; 4-Trifluoromethylphenyl ; 3-Fluorophenyl ; Synthesis ; Anticancer activity ; Anti-TMV activity ; Microwave irradiation
• 刊名：Journal of Fluorine Chemistry
• 出版年：2006
• 期刊代码：52_00221139
• 类别：ch
• 出版时间：January 2006
• 卷：127
• 期：1
• 页码：48-53
• 文件大小：142 K

摘要

A series of novel dialkyl (4-trifluoromethylphenylamino)-(4-trifluoromethyl or 3-fluorophenyl) methylphosphonates 3 were synthesized through the reaction of 3-fluorobenzaldehyde or 4-trifluoromethylbenzaldehyde and 4-trifluoromethylaniline with dialkyl phosphite by microwave irradiation using boron trifluoride-ether catalyst and their structures were clearly verified by spectroscopic data (IR, ¹H NMR and elemental analysis). The results of bioassay showed that these title compounds possess potential anticancer activities in vitro by MTT method. At the same time, we found these title compounds exhibit moderate antiviral activity against tobacco mosaic virus.