Radiosynthesis of [¹⁸F] N-3-fluoropropyl-2-β-carbomethoxy-3-β(4′ methylphenyl) nortropane (FPCMT)

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• 作者：Chaly Jr ; Thomas ; Matacchieri ; Ralph ; Dahl ; Robert ; Dhawan ; Vijay ; Eidelberg ; David
• 刊名：Applied Radiation and Isotopes
• 出版年：1999
• 期刊代码：6_09698043
• 类别：ce
• 出版时间：September, 1999
• 卷：51
• 期：3
• 页码：299-305
• 文件大小：168 K

摘要

A synthetic procedure for the routine preparation of [¹⁸F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4′ methylphenyl) nortropane (¹⁸F FPCMT) has been developed. The synthesis is based on alkylation of nortropane with ¹⁸F labeled fluoropropyl tosylate. Purification of the final product was achieved by a preparative HPLC procedure using Alltech Econosil column. Separation of the desired compound was achieved and the product was clean. The radiochemical yield (without decay correction) is 4 to 5%, calculated at the end of the synthesis based on the total amount of fluorine recovered from the target. Radiochemical purity was in the range of 98 to 99%.