- 作者：Nirali S. Desai ; M.D.a ; Nestani Tukvadze ; M.D.b ; Jennifer K. Frediani ; M.S. ; R.D. ; L.D.c ; d ; Maia Kipiani ; M.D.b ; Ekaterine Sanikidze ; Ph.D.b ; Memorie M. Nichols ; P.A.-C.d ; Gautam Hebbar ; M.B.B.S. ; M.P.H.e ; Russell R. Kempker ; M.D.f ; Veriko Mirtskhulava ; M.D. ; M.P.H.b ; Iagor Kalandadze ; Ph.D.b ; Shabnam Seydafkan ; M.D.e ; Nilay Sutaria ; B.A.g ; Tai C. Chen ; Ph.D.g ; Henry M. Blumberg ; M.D.a ; c ; f ; Thomas R. Ziegler ; M.D.c ; d ; e ; Vin Tangpricha ; M.D. ; Ph.D.c ; d ; e ; h ; vin.tangpricha@emory.edu
- 关键词：Cholecalciferol ; 7-Dehydrocholesterol ; Dietary intake
- 刊名：Nutrition
- 出版年：2012
- 期刊代码：81_08999007
- 类别：abs
- 出版时间：April, 2012
- 卷：28
- 期：4
- 页码：362-366
- 文件大小：242 K
Objective
Vitamin D deficiency is common in tuberculosis (TB) and this may modulate immune responses. This study investigated vitamin D status in patients with TB and examined the sources of vitamin D in Tbilisi, Georgia.Methods
We measured plasma 25-hydroxyvitamin D (25[OH]D) and dietary vitamin D intake in patients with pulmonary TB (n = 85) in Tbilisi, Georgia. To determine the impact of season on vitamin D status, we tested the in聽vitro conversion of 7-dehydrocholesterol (7-DHC) to previtamin D3 after sunlight exposure.
Results
In subjects with TB, mean plasma 25(OH)D concentrations were 14.4 卤 7.0 ng/mL, and vitamin D insufficiency (25[OH]D <30 ng/mL) occurred in 97%of subjects. The dietary sources of vitamin D were mainly fish, eggs, and butter. The daily intake was well below recommended daily intakes in subjects with TB (172 卤 196 IU). The conversion of 7-DHC to previtamin D3 was undetectable from October to March and highest in June and July from 11:00 to 14:00 h.
Conclusion
An insufficient vitamin D dietary intake and a limited production of vitamin D from sunlight for most of the year may explain the high prevalence of vitamin D insufficiency in patients with TB in Tbilisi.