Quantitative Ultrasound Bone Measurements in Pre-Pubertal Children with Type 1 Diabetes

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• 作者：Agata P. Chobot^&lowast ; ; ^{agata.chobot@gmail.com} ; Anna Haffke^&dagger ; ; Joanna Polanska^&Dagger ; ; Zenon P. Halaba^§ ; ; Grazyna Deja^鈥?/sup> ; Przemyslawa Jarosz-Chobot^|| ; Wojciech Pluskiewicz^¶ ;
• 关键词：Bone ; Children ; HbA1c ; Quantitative ultrasound ; Type 1 diabetes
• 刊名：Ultrasound in Medicine and Biology
• 出版年：2012
• 期刊代码：82_03015629
• 类别：ph
• 出版时间：July, 2012
• 卷：38
• 期：7
• 页码：1109-1115
• 文件大小：153 K

摘要

This case-control study aimed to assess bone status in children with type 1 diabetes mellitus (T1DM). Fifty-seven pre-pubertal patients (37 boys, aged 7.9 卤 2.5 years, T1DM duration 3.1 卤 1.6 years) and 171 age-matched healthy controls (111 boys) were studied. Quantitative ultrasound (QUS) was used to measure amplitude dependent speed of sound (Ad-SoS) at hand phalanges (expressed as standard deviation score [SDS]). Anthropometric and disease-related data (including mean HbA_1c from whole T1DM duration [T], last year [Y], examination day [D]) were collected. Mean Ad-SoS SDS in patients 鈭?.13 卤 1.32 (95%confidence interval [CI] 鈭?.48, 0.22) was similar to that of controls. Subgroups discriminated according to HbA_1c D, Y and T (cut-off 7.0%) did not differ regarding analyzed parameters. In patients, Ad-SoS SDS was comparable for both genders. Multivariable stepwise regression analysis showed significant negative influence of diabetes duration on Ad-SoS SDS. QUS findings in pre-pubertal children with T1DM do not differ from those in healthy children. Disease duration seems to affect negatively Ad-SoS SDS. However, independent prospective studies are needed to elucidate the true associations.