Novozym 435-catalyzed synthesis of polyetheramides from amino-esters, or diesters and diamines built on ethylene- and diethylene- glycol moieties

详细信息	查看全文 | 推荐本文 |

• 作者：Florent Poulhè ; s^a ; Dominique Mouysset^a ; Gé ; rard Gil^b ; ^{Gerard.gil@univ-cezanne.fr} ; Michè ; le P. Bertrand^a ; ^{michele.bertrand@univ-cezanne.fr} ; Sté ; phane Gastaldi^a ; ^{stephane.gastaldi@univ-cezanne.fr}
• 关键词：Polyetheramides ; Enzymatic polymerization ; CAL-B
• 刊名：Polymer
• 出版年：2012
• 期刊代码：83_00323861
• 类别：ms
• 出版时间：9 March, 2012
• 卷：53
• 期：6
• 页码：1172-1179
• 文件大小：695 K

摘要

The optimization of CAL-B-promoted (Novozym 435) A/B and AA/BB type polymerizations leading to polyetheramides, from amino ethylesters or diethyl esters and diamines based on ethylene- or diethylene-glycol moieties, is disclosed herein. From these preliminary experiments it became obvious that it is of prime importance: to avoid the presence of water by carefully drying the enzyme prior to use; to eliminate ethanol from the reaction medium, by working under reduced pressure in order to drive the amidation reaction forward; to select an appropriate high boiling solvent, the best choice being diphenyl ether. Under such experimental conditions, polyetheramides were obtained in 70-80%yield with an average degree of polymerization (DPn) up to 17.