Et₃N-catalyzed oxidative dehydrogenative coupling of α-unsubstituted aldehydes and ketones with aryl diamines leading to quinoxalines using molecular oxygen as oxidant

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• 作者：Chun Zhang^a ; Zejun Xu^a ; Liangren Zhang^a ; Ning Jiao^a ; ^b ; ^{jiaoning@bjmu.edu.cn}
• 关键词：C&ndash ; H activation ; Aerobic oxidation ; Dehydrogenation ; Organocatalysis metal free ; Molecular oxygen
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：1 July, 2012
• 卷：68
• 期：26
• 页码：5258-5262
• 文件大小：485 K

摘要

A novel Et₃N-catalyzed oxidative dehydrogenative coupling of α-unsubstituted carbonyl compounds with aryl diamines leading to quinoxaline derivatives using molecular oxygen as oxidant has been developed. Six hydrogen dissociations involving 2 sp³ C-H bonds activation are realized under mild?conditions in this approach. Plausible mechanism is proposed for this novel Et₃N-catalyzed transformation on the basis of the aboratively designed mechanistic studies including the radical detection by EPR. ^?2012 Elsevier Science. All rights reserved.