• 作者：Isabel Blanco ; ^&diams ; ; ^{isabeldoctora@yahoo.es} ; Claudio Villaquirá ; n^&diams ; &diams ; ; José ; Luis Valera ; Marí ; a Molina-Molina ; Antoni Xaubet ; Robert Rodrí ; guez-Roisin ; Joan A. Barberà ; Josep Roca
• 关键词：Ejercicio cardiopulmonar ; Fibrosis pulmonar idiopá ; tica ; Consumo de oxí ; geno ; Hipertensió ; n pulmonar ; Prueba de marcha de seis minutos
• 刊名：Archivos de Bronconeumolog铆a
• 出版年：2010
• 期刊代码：pca65_03002896
• 类别：med
• 出版时间：March 2010
• 卷：46
• 期：3
• 页码：122-128
• 文件大小：252 K

Introduction

The six-minute walk test (6MWT) is widely used in evaluating diffuse interstitial lung disease (ILD) and pulmonary hypertension (PH). However, their physiological determining factors have not been well defined.

Objective

To evaluate the physiological changes that occur in ILD and PH during the 6MWT, and compare them with the cardiopulmonary exercise test (CPET).

Material and methods

Thirteen patients with ILD and 14 with PH were studied using the 6MWT and CPET on an ergometer cycle. The respiratory variables were recorded by means of telemetry during the 6MWT.

Results

Oxygen consumption (VO₂), respiratory and heart rate reached a plateau from minute 3 of the 6MWT in both diseases. The VO₂ did not differ from the peak value in the CPET (14卤2 and 15卤2 ml/kg/min, respectively, in ILD; 16卤6 and 16卤6 ml/kg/min, in PH). The arterial oxygen saturation decreased in both diseases, although it was more marked in ILD (鈭?2卤5%, p<0,01). The ventilatory equivalent for CO₂ (V_E/VCO₂) in PH during the 6MWT was strongly associated with functional class (FC) (85卤14 in FC III-IV, 44卤6 in FC I-II; p<0,001).

Conclusions

The 6MWT in ILD and PH behaves like a maximal effort test, with similar VO₂ to the CPET, demonstrating a limit in oxygen transport capacity. Monitoring using telemetry during the 6MWT may be useful for the clinical evaluation of patients with ILD or PH.