Changes in arterial blood pressure after single oral administration of cuttlefish (Sepia officinalis) muscle derived peptides in spontaneously hypertensive rats

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• 作者：Rafik Balti^a ; ^b ; ^{rafikbalti1981@gmail.com} ; Ali Bougatef^a ; Didier Guillochon^b ; Pascal Dhulster^b ; Moncef Nasri^a ; Naima Nedjar-Arroume^b
• 关键词：ACE ; angiotensin-I-converting enzyme ; DBP ; diastolic blood pressure ; SBP ; systolic blood pressure ; SHR ; spontaneously hypertensive rats ; BW ; body weight
• 刊名：Journal of Functional Foods
• 出版年：2012
• 期刊代码：P18_17564646
• 类别：bio
• 出版时间：July, 2012
• 卷：4
• 期：3
• 页码：611-617
• 文件大小：214 K

摘要

In this study we evaluated the short-term oral antihypertensive effect of several peptide sequences isolated from cuttlefish (Sepia officinalis) muscle proteins hydrolysates, previously characterized as in vitro angiotensin-I-converting enzyme-inhibitors, in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP) and the diastolic blood pressure (DBP) of the rats were measured by the tail cuff method before administration and also 2, 4, 6, 8 and 24 h post-administration. The peptide sequences Val-Tyr-Ala-Pro, Val-Ile-Ile-Phe and Ala-His-Ser-Tyr showed a clear decrease in SBP and DBP in SHR. Met-Ala-Trp caused a significant decrease of the SBP in the SHR, but this sequence caused a slight decrease in DBP in these animals. SBP and DBP returned to baseline values 24 h post-administration of all peptides. Thus, these peptides are bioactive ingredients with potential benefit in the prevention and treatment of hypertension.