Effects of low dose tryptophan depletion on emotional processing in dieters

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• 作者：A. Pringle^a ; ^{abbie.pringle@psych.ox.ac.uk} ; M.J. Cooper^b ; M. Browning^a ; C.J. Harmer^a
• 关键词：Serotonin ; Emotional processing ; Tryptophan depletion ; Attention ; Eating disorders
• 刊名：Eating Behaviors
• 出版年：2012
• 期刊代码：83_14710153
• 类别：med
• 出版时间：April, 2012
• 卷：13
• 期：2
• 页码：154-157
• 文件大小：221 K

摘要

Biased processing of ED-relevant stimuli (eg Fairburn, Shafran, & Cooper, 1999) and 5-HT function (Kaye, Fudge, & Paulus, 2009) are implicated in vulnerability to and the maintenance of eating disorders (EDs), but it is not known if these findings are connected: Could manipulating 5-HT function affect the processing of ED-relevant stimuli? To address this question we assessed emotional processing in female dieters (T + n = 12, T 鈭?#xA0;n = 14) following acute low dose tryptophan depletion. ATD increased interference in the masked condition of the emotional Stroop to all negative emotional stimuli, in the absence of any other differences in emotional processing. These results suggest that ATD affects the processing of some negative (including ED-relevant) stimuli, and that reduced 5-HT function may be involved in some aspects of psychological vulnerability to EDs.