Proliferation and differentiation of neural stem cells irradiated with X-rays in logarithmic growth phase

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• 作者：Mayu Isono^a ; ^b ; Masahiro Otsu^a ; ^c ; Teruaki Konishi^b ; Kana Matsubara^d ; Toshiaki Tanabe^a ; Takashi Nakayama^e ; Nobuo Inoue^a ; ^{juninoue@hs.tmu.ac.jp}
• 关键词：Neural stem cells ; Embryonic stem cells ; X-irradiation ; Capabilities for proliferation and differentiation
• 刊名：Neuroscience Research
• 出版年：2012
• 期刊代码：53_01680102
• 类别：neu
• 出版时间：July, 2012
• 卷：73
• 期：3
• 页码：263-268
• 文件大小：498 K

摘要

Exposure of the fetal brain to ionizing radiation causes congenital brain abnormalities. Normal brain formation requires regionally and temporally appropriate proliferation and differentiation of neural stem cells (NSCs) into neurons and glia. Here, we investigated the effects of X-irradiation on proliferating homogenous NSCs prepared from mouse ES cells. Cells irradiated with X-rays at a dose of 1 Gy maintained the capabilities for proliferation and differentiation but stopped proliferation temporarily. In contrast, the cells ceased proliferation following irradiation at a dose of >5 Gy. These results suggest that irradiation of the fetal brain at relatively low doses may cause congenital brain abnormalities as with relatively high doses.