Physiochemical properties and prolonged release behaviours of chitosan-denatured 尾-lactoglobulin microcapsules for potential food applications
- 作者：Pei Sia Lee sherrene_lps@yahoo.com.sg ; Sun Goo Yim sunnypanda@hanmail.net ; Yeri Choi yeri86@sju.ac.kr ; Thi Van Anh Ha havananh.vn@gmail.com ; Sanghoon Ko ; sanghoonko@sejong.ac.kr
- 关键词：Chitosan ; 尾-Lactoglobulin ; Microcapsule ; Prolonged release ; In vitro digestion
- 刊名：Food Chemistry
- 出版年：2012
- 期刊代码：48_03088146
- 类别：abs
- 出版时间：15 September, 2012
- 卷：134
- 期：2
- 页码：992-998
- 文件大小：462 K
摘要
Chitosan (CS) and 尾-lactoglobulin (尾lg) double-wall coating was designed as a shell structure to achieve prolonged release of core material in the gastrointestinal tract (GI) for potential food applications. A model core material, brilliant blue (BB) dye, was incorporated into CS as the primary wall material, and subsequently, denatured 尾lg, a secondary wall material, was used to coat the outer layer. The strongest interaction occurred between 0.5%(w/v) 尾lg and 0.5%(w/v) CS at pH 5.5 卤 0.1, where the opposite charges of CS and 尾lg formed a complex, which is especially favourable in acidic beverage systems. Under simulated stomach conditions, a denatured-尾lg coat resisted acid conditions and pepsin hydrolysis for 2 h. While mimicking small intestine conditions, 尾lg was degraded by pancreatin, causing the release of BB-loaded CS to the intestinal fluid at a constant rate. The sustained release of core material later in the GI tract provided an optimal absorption rate in the small intestine.