The first case of diastereoselective cycloadditions of enantiopure nitrilimines in aqueous media
- 作者：Molteni ; Giorgio
- 刊名：Tetrahedron ; Asymmetry
- 出版年：2004
- 期刊代码：108_09574166
- 类别：ch
- 出版时间：April 5, 2004
- 卷：15
- 期：7
- 页码：1077-1079
- 文件大小：242 K
摘要
The diastereoselective cycloadditions of enantiopure nitrilimines 4 with ethyl acrylate were exploited in dry toluene and in aqueous sodium hydrogencarbonate as reaction media. Shorter reaction times and improved diastereoisomeric ratios of the resulting 5-ethoxycarbonyl-4,5-dihydropyrazoles 5 and 6 were observed in aqueous media.