Studies of interaction between iron (III) and intermediates of synthetic neuromelanin by means of cyclic voltammetry of and dopamine
- 作者：Jianguo Wang ; Yuling Wang ; Hui Lv ; Fei Hui ; Yong Ma ; Shijian Lu ; Qiuju Sha and Erkang Wang
- 关键词：Parkinson’ ; s disease ; Iron ; Dopamine ; auto-oxidation ; Neuromelanin ; Cyclic voltammetry
- 刊名：Journal of Electroanalytical Chemistry
- 出版年：2006
- 期刊代码：27_00220728
- 类别：ph
- 出版时间：15 August 2006
- 卷：594
- 期：1
- 页码：59-64
- 文件大小：410 K
摘要
Neuromelanin is a complex polymer pigment found primarily in the dopaminergic neurons of the human substantia nigra, whose composition is complex including production of dopamine auto-oxidation, glutathione and a variety of amino acid. Neuromelanin forms stable complex with iron (III). We observed that 5,6-dihydroxyindole and its ramification possessed strong ability of chelating iron (III), and they are the production of dopamine auto-oxidation under physiological pH condition. In the present of l-cysteine, the relative yields of electrochemical oxidation of dopamine also had strong ability of chelating iron (III). The experimental results suggest that 5,6-dihydroxyindole and 5-S-cysteineldopamine play important roles in the process of synthetic neuromelanin chelating iron (III).