Maternal micronutrient supplementation and child survival
- 作者：Frank T Wieringa ; Marjoleine A Dijkhuizen ; Jos W van der Meer
- 关键词：
//www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">-Glucosidase ; Diabetes ; Syzygium cumini ; Eugenia jambolana ; Goto– ; Kakizaki rats
- 刊名：The Lancet
- 出版年：2008
- 期刊代码：182_01406736
- 类别：med
- 出版时间：24 May 2008-30 May 2008
- 卷：371
- 期：9626
- 页码：1751-1752
- 文件大小：53 K
摘要
Syzygium cumini seed kernel extracts were evaluated for the inhibition of 
www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">-glucosidase from mammalian (rat intestine), bacterial (Bacillus stearothermophilus), and yeast (Saccharomyces cerevisiae, baker’s yeast). In vitro studies using the mammalian www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">-glucosidase from rat intestine showed the extracts to be more effective in inhibiting maltase when compared to the acarbose control. Since acarbose is inactive against both the bacterial and the yeast enzymes, the extracts were compared to 1-deoxynojirimycin. We found all extracts to be more potent against www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">-glucosidase derived from B. stearothermophilus than that against the enzymes from either baker’s yeast or rat intestine. In an in vivo study using Goto–Kakizaki (GK) rats, the acetone extract was found to be a potent inhibitor of www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">-glucosidase hydrolysis of maltose when compared to untreated control animals. Therefore, these results point to the inhibition of www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">-glucosidase as a possible mechanism by which this herb acts as an anti-diabetic agent.