Synthesis, characterization, and anticancer activity of ruthenium-pyrazole complexes

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• 作者：Solene David^a ; Richard S. Perkins^a ; Frank R. Fronczek^b ; Sahba Kasiri^c ; Subhrangsu S. Mandal^c ; Radhey S. Srivastava^a ; ^{rss1805@louisiana.edu}
• 关键词：Ruthenium(III)pyrazole complexes ; Crystal structure cyclic voltammetry ; in vitro cytotoxicity
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2012
• 期刊代码：53_01620134
• 类别：ch
• 出版时间：June, 2012
• 卷：111
• 期：Complete
• 页码：33-39
• 文件大小：633 K

摘要

A series of new water soluble Ru(III) pyrazole complexes mer-[RuCl₃(DMSO-S)(pyz)₂] 1, mer-[RuCl₃(DMSO-S)(DMSO-O)(pyz)] 2, mer-[RuCl₃(bpy)(dmpyz)] 3, and mer-[RuCl₃(DMSO-S)(dmpyz)₂] 4 (pyz = pyrazole; dmpyz = 3,5-dimethylpyrazole, bpy = 2,2鈥?bipyridine) have been synthesized and characterized by use of a combination of spectroscopy (IR and UV-visible), X-ray diffraction, and cyclic voltammetry. The molecular X-ray structure of all reported compounds (1-4) revealed distorted octahedral coordination around ruthenium. The cytotoxicity assay on human breast cancer cells (MCF7) demonstrated that compounds 1 and 4 affect cell viability, whereas compounds 2 and 3 do not show appreciable activity. The IC₅₀ values for 1 and 4 lie within the range of 71-32 渭M in MCF7 cells.