Simplified parametric methods for [¹⁸F]FDDNP studies

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• 作者：Maqsood Yaqub ; Nelleke Tolboom ; Bart N.M. van Berckel ; Philip Scheltens ; Adriaan A. Lammertsma ; Ronald Boellaard
• 关键词：[¹⁸F]FDDNP ; Parametric methods ; PET ; Kinetic modelling ; Reference tissue models
• 刊名：NeuroImage
• 出版年：2010
• 期刊代码：83_10538119
• 类别：neu
• 出版时间：1 January 2010
• 卷：49
• 期：1
• 页码：433-441
• 文件大小：494 K

摘要

The purpose of the present study was to evaluate the performance of various parametric methods for quantification of [¹⁸F]FDDNP studies. All parametric methods tested were based on the use of a reference tissue and they were compared with the simplified reference tissue model (SRTM), as previously it has been shown that SRTM is the method of choice for analysing [¹⁸F]FDDNP studies, even when an arterial plasma input function is available. The following parametric methods were evaluated: receptor parametric mapping (basis function implementation of SRTM; with and without fixing the reference tissue efflux rate constant k′₂), reference Logan and several multi-linear reference tissue methods (again with and without fixing k′₂). Simulations were used to assess the effects of variation in relative flow (R₁), fractional blood volume (V_b) and binding potential (BP_ND) on precision and accuracy of estimated BP_ND. For clinical data, best performance was obtained using receptor parametric mapping (RPM2) and one of the multi-linear reference tissue models (MRTM2), with k′₂ being fixed in both methods. These models showed good correlation with SRTM, their BP_ND results were less affected by noise and images showed good contrast. Furthermore, in simulations, RPM2 and MRTM2 provided the most accurate and precise BP_ND estimates. RPM2 and MRTM2 are the methods of choice for parametric analysis of [¹⁸F]FDDNP studies.