Post-operative respiratory rehabilitation after lung resection for non-small cell lung cancer

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• 作者：Alfredo Cesario ; Luigi Ferri ; Domenico Galetta ; Franco Pasqua ; Stefano Bonassi ; Enrico Clini ; Gianluca Biscione ; Vittorio Cardaci ; Stefania di Toro ; Alessia Zarzana ; Stefano Margaritora ; Alessio Pirai
• 关键词：Non-small cell lung cancer ; Pulmonary rehabilitation ; Surgery
• 刊名：Lung Cancer
• 出版年：2007
• 期刊代码：187_01695002
• 类别：med
• 出版时间：August 2007
• 卷：57
• 期：2
• 页码：175-180
• 文件大小：228 K

摘要

To investigate the efficacy of an inpatient Pulmonary Rehabilitation program (i-PR) after lung resection (LR) for Non-Small Cell Lung Cancer (NSCLC).

Patients and methods

From January 2001 to December 2004, 211 out of 618 patients who underwent LR were considered eligible for i-PR. Twenty-five patients accepted the i-PR and were included in the case group. The remaining 186 who refused i-PR were taken as controls.

Results

The two study groups were comparable for demographic and surgical characteristics, as well as for the peri-operative morbidity (4%in the controls and 3%among patients undergoing i-PR). Most functional parameters among treated patients were improved when baseline versus 1-month figures were compared, despite the strong correction for multiple comparison limited statistical significance to Borg scale dyspnoea on exertion – median – (2 versus 0; p < 0.01); pH (7.45 versus 7.42; p < 0.05); timed walk-6MWD (297.8 m versus 393.4 m; p < 0.01) and Hb saturation during 6 MWD (95.4%versus 93.9%; p < 0.05). On the contrary, global function in the group of controls was homogeneously decreased (FEV₁ and PEF p < 0.01) after operation. The comparison of treated and untreated patients 1 month after the operation did not show any significant difference in terms of FEV₁, FVC, PEF, distance, Hb saturation, and KCO that instead were homogeneously and significantly worse at baseline (before the surgical operation) in the case group.

Conclusions

Respiratory Function and exercise capacity significantly improve following a post-operative 4-week i-PR in lung resected patients. i-PR could be regarded as a component of the management of patients who have undergone LR for cancer.