“Determination of domperidone in tablet dosage form by anodic differential pulse voltammetry”
- 作者：Tarek Wahdan and Nadia Abd El-Ghany
- 关键词：Domperidone ; Differential pulse voltammetry ; Glassy carbon electrode ; Electrochemical oxidation ; Pharmaceutical analysis
- 刊名：Il Farmaco
- 出版年：2005
- 期刊代码：34_0014827x
- 类别：ch
- 出版时间：2005
- 卷：60
- 期：10
- 页码：830-833
- 文件大小：218 K
摘要
A differential pulse voltammetric method was described for the determination of domperidone. The method was based on the anodic oxidation of domperidone on a glassy carbon electrode at +0.64 V vs. SCE in Britton–Robinson buffer solution of pH 2.3. The reversibility of the oxidation was tested by cyclic voltammetry; the electrode process is irreversible and diffusion–adsorption controlled. Calibrations are linear over the range 1.0 × 10–6–2.0 × 10–5 M of domperidone with a detection limit of 4.0 × 10–7 M. The method was applied, without any interference from the excipients, to the determination of the drug in a tablet dosage form.