Results showed that the immobilization procedure did not alter the catalytic properties of the enzyme. The immobilised tyrosinase showed high stability over 30 h. In a continuous bioreactor the specific activity of tyrosinase is higher than that obtained with the free enzyme and those reported in the literature. The continuous operation minimizes the oxidation of the l-DOPA and for this reason the productivity (22.54 mg L<sup>鈭?sup> h<sup>鈭?sup>) is 95%higher than that obtained with the total recycle reactor.
Results obtained in the present study are promising for the development of the bioreactor at larger scale.