Acremolin, a new 1H-azirine metabolite from the marine-derived fungus Acremonium strictum

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• 作者：Elin Julianti^a ; Hana Oh^a ; Hyi-Seung Lee^b ; Dong-Chan Oh^a ; Ki-Bong Oh^c ; ; Jongheon Shin^a ; ^{shinj@snu.ac.kr}
• 关键词：Acremolin ; A modified base ; 1H-Azirine functionality ; Marine fungus ; Acremonium strictum
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：6 June, 2012
• 卷：53
• 期：23
• 页码：2885-2886
• 文件大小：295 K

摘要

Acremolin (1), a novel modified base, was isolated from the culture broth of the marine fungus Acremonium strictum. Based on combined spectroscopic analyses, the structure of this compound was that of a methyl guanine base containing an isoprene unit. In addition, the presence of a 1H-azirine moiety is unprecedented among natural products. This compound exhibited weak cytotoxicity against an A549 cell line.