• 作者：Juliá ; n Arista-Nasr ; Rita Dorantes-Heredia ; Norma Uribe-Uribe ; Karen Rocí ; o Arispe-Angulo ; Francisco Javier Llamas-Gutié ; rrez ; ^{xavre@hotmail.com} ; ^{xavre2@hotmail.com}
• 关键词：Adenosis ; Pró ; stata ; Zona perifé ; rica
• 刊名：Revista Espa帽ola de Patolog铆a
• 出版年：2011
• 期刊代码：pca318_16998855
• 类别：med
• 出版时间：April-June 2011
• 卷：44
• 期：2
• 页码：127-131
• 文件大小：873 K

Prostatic diffuse adenosis of the peripheral zone (DAPZ) is a recently described entity (Lotan and Epstein, 2008). It characteristically shows densely packed small acini and small or medium size glands irregularly spread along the peripheral zone, which can simulate prostatic adenocarcinoma. Most patients are men under 55 years of age, with mild PSA elevations (mean 5.4 ng/mL).

We present two cases of DAPZ. Although needle core biopsies had some areas resembling adenocarcinoma, immunostaining demonstrated the presence of basal cells in glands showing a pseudoinfiltrative pattern. It must be emphasized that prostatic peripheral zone diffuse adenosis is a risk factor for adenocarcinoma and that in nearly 50%of cases adenocarcinoma will be found in subsequent biopsies.