Features of time-intensity curve parameters of colorectal adenocarcinomas evaluated by double-contrast enhanced ultrasonography: Initial observation

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• 作者：Hua Zhuang^a ; Zhi-gang Yang^b ; ^{yangzg6666@yahoo.com.cn} ; Zi-qiang Wang^c ; Xiao-dong Wang^c ; Hui-jiao Chen^d ; Yuan-chuan Zhang^c ; Yan Luo^a
• 关键词：Colorectal adenocarcinoma ; Hydrocolonic ultrasonography ; Time intensity curve parameters
• 刊名：European Journal of Radiology
• 出版年：2012
• 期刊代码：93_0720048x
• 类别：med
• 出版时间：April, 2012
• 卷：81
• 期：4
• 页码：677-682
• 文件大小：727 K

摘要

Purpose

This study is to investigate the value of double contrast-enhanced ultrasonography (DCEU) in assessing microcirculation of colorectal adenocarcinomas and to describe the perfusion features of the tumours.

Material and methods

DCEUS was performed in 42 patients with adenocarcinoma. The time-intensity curve parameters (arrival time (AT), time-to-peak (TTP), peak intensity (PI) and area under the curve (AUC)) within the tumours were extracted. The parameters were compared among the tumours with different CEUS features and stages.

Results

The mean values of AT, TTP, PI and AUC of the colorectal adenocarcinomas were 13.68 卤 13.36 s, 32.61 卤 19.56 s, 19.82 卤 16.54 dB and 271.10 卤 159.19 dB s, respectively. In the adenocarcinomas with necrosis, the mean values of AUC was significantly lower than that of the adenocarcinomas without (231.10 卤 219.27 dB s, 278.10 卤 123.20 dB s, p = 0.004). In the adenocarcinomas with necrosis, the AUC and PI of the non-necrotic part were significantly higher than that of the necrotic part (p = 0.007, 0.0025, respectively). AUC increased progressively in the subgroups of T2, T3 and T4 and the difference of AUC between T2 and T4 subgroup was significant (p = 0.008).

Conclusions

Double contrast-enhanced ultrasonography is a valuable technique for quantifying tumour vascularity of colorectal adenocarcinomas. AUC was significantly different in the subgroups of different T stage. AUC and PI could reflect the different perfusion status of tumours with or without necrosis.