Breast: A rare localization of schistosomiasis

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• 作者：Guillaume Ducarme ; Nathalie Seince ; Bruno Poulet ; Vincent Jeantils ; Michè ; le Uzan
• 关键词：Negative cytology ; HPV ; Hybrid capture II ; Follow-up ; CIN ; Incident abnormalities
• 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
• 出版年：2007
• 期刊代码：92_03012115
• 类别：med
• 出版时间：August 2007
• 卷：133
• 期：2
• 页码：247-248
• 文件大小：261 K

摘要

To assess the role of HPV as determinant of the incident cytological abnormalities (SIL) and cervical lesions (CIN) during a 24-month follow-up of baseline PAP smear-negative subgroup of women included in the Latin American Screening study (LAMS).

Study design

A group of 365 women with normal Pap smear and negative or positive high-risk Hybrid Capture II test were prospectively followed-up for 24 months at Campinas and São Paulo (Brazil). The incidence rate (IR) and risk ratio (RR and 95%CI) of developing cytological or histological abnormality during the follow-up was calculated for HPV-negative and HPV-positive women.

Results

During the 12-month follow-up, women HPV-positive at baseline had developed a significantly higher rate of incident LSIL (IR = 3.5%, RR = 1.4; 95%CI 1.1–1.7) and HSIL (IR = 0.7%, RR = 1.5; 95%CI 1.4–1.7) abnormality. For HSIL, the IR increased to 2.1%and the RR increased to 1.7 (95%CI 1.5–1.9) among those followed for 24 months. Similarly, women with positive HPV tests were at a higher risk of developing CIN 2–3 (IR = 2.6%, RR = 1.5; 95%CI 1.4–1.6) during the first 12 months of follow-up, and for those followed for 24 months, this RR increased further to 1.7 (95%CI 1.5–1.9) although the IR was 0.7%.

Conclusions

Oncogenic HPV infections comprise a significant risk factor for incident cervical abnormalities, and HPV test is a useful adjunct to cytology in detecting the high-risk patients among baseline PAP smear-negative women.