Acentrosomal spindle assembly and chromosome segregation during oocyte meiosis

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• 作者：Julien Dumont¹ ; ^{dumont@ijm.univ-paris-diderot.fr} ; Arshad Desai²
• 刊名：Trends in Cell Biology
• 出版年：2012
• 期刊代码：254_09628924
• 类别：med
• 出版时间：May, 2012
• 卷：22
• 期：5
• 页码：241-249
• 文件大小：1402 K

摘要

The ability to reproduce relies in most eukaryotes on specialized cells called gametes. Gametes are formed by the process of meiosis in which, after a single round of replication, two successive cell divisions reduce the ploidy of the genome. Fusion of gametes at fertilization reconstitutes diploidy. In most animal species, chromosome segregation during female meiosis occurs on spindles assembled in the absence of the major microtubule-organizing center, the centrosome. In mammals, oocyte meiosis is error prone and underlies most birth aneuploidies. Here, we review recent work on acentrosomal spindle formation and chromosome alignment/separation during oocyte meiosis in different animal models.