Synthesis of crown ether modified cation exchange polymer particles for ⁹⁰Sr urinalysis

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• 作者：Amy Hrdina^a ; Edward Lai^a ; ^{edward_lai@carleton.ca} ; Chunsheng Li^b ; Baki Sadi^b ; Gary H. Kramer^b
• 关键词：Crown ether ; Ion imprinting ; Surface immobilization ; Strontium-90
• 刊名：Reactive and Functional Polymers
• 出版年：2012
• 期刊代码：92_13815148
• 类别：ch
• 出版时间：May, 2012
• 卷：72
• 期：5
• 页码：295-302
• 文件大小：956 K

摘要

Cation exchange polymer particles have been synthesized for urinalysis to monitor levels of strontium-90 (⁹⁰Sr) exposure in humans. Two techniques were utilized in the incorporation of a Sr²⁺ selective chelating agent, di-tert-butyl-cyclohexano-18-crown-6 (DtBuCH18C6). The ion imprinting technique involved entrapment of DtBuCH18C6 during the formation of 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) polymer particles. In the surface immobilization technique, adsorption of DtBuCH18C6 onto the surface of AMPS polymer particles was assisted by a molecular modifier. Ethylene glycol dimethacrylate (EGDMA) and divinylbenzene (DVB) were evaluated as cross-linking agents to provide better support for DtBuCH18C6. These polymer particles were characterized by scanning electron microscopy, dynamic light scattering, and Fourier transform infrared spectroscopy. Radiometric binding assays demonstrated that surface immobilization, in comparison to matrix imprinting, achieved greater Sr²⁺ uptake. Application of the surface immobilized particles in urinalysis was successful, attaining 86 卤 2%⁹⁰Sr uptake at pH 9.