Hydrophobic polymer monoliths as novel phase separators: Application in continuous liquid-liquid extraction systems

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• 作者：Daniela Peroni^a ; ^{D.Peroni@uva.nl} ; Dominique Vanhoutte^a ; Francisco Vilaplana^a ; Peter Schoenmakers^a ; Sjaak de Koning^b ; Hans-Gerd Janssen^a ; ^c
• 关键词：Gas chromatography ; Chip-based liquid&ndash ; liquid extraction ; Phase separation ; Monoliths
• 刊名：Analytica Chimica Acta
• 出版年：2012
• 期刊代码：2_00032670
• 类别：ch
• 出版时间：30 March, 2012
• 卷：720
• 期：Complete
• 页码：63-70
• 文件大小：629 K

摘要

Hydrophobic macroporous polymer monoliths are shown to be interesting materials for the construction of 鈥渟elective solvent gates鈥? With the appropriate surface chemistry and porous properties the monoliths can be made permeable only for apolar organic solvents and not for water. Different poly(butyl methacrylate-co-ethylene dimethacrylate) (BMA-EDMA) and poly(styrene-co-divinylbenzene) (PS-DVB) monoliths prepared with tailored chemistries and porosities were evaluated for this purpose. After extensive characterization, the PS-DVB monoliths were selected due to their higher hydrophobicity and their more suitable flow characteristics. BMA-EDMA monoliths are preferred for mid-polarity solvents such as ethyl acetate, for which they provide efficient separation from water. Breakthrough experiments confirmed that the pressures necessary to generate flow of organic solvents through PS-DVB monoliths were substantially lower than for water. A phase separator was constructed using the monoliths as the flow selector. This device was successfully coupled on-line with a chip-based continuous liquid-liquid-extraction (LLE) system with segmented flow. Efficient separation of different solvents was obtained across a wide range of flow rates (0.5-4.0 mL min^鈭?) and aqueous-to-organic flow ratios (尾 = 1-10). Good robustness and long life-time were also confirmed. The suitability of the device to perform simple, cheap, and reliable phase separation in a continuous LLE system prior to gas-chromatographic analysis was proven for some selected real-life applications.