Modelling the influence of thermal effects induced by radio frequency electric field on the dynamics of the ATPase nano-biomolecular motors

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• 作者：A. Lohrasebi^a ; ^b ; S. Mohamadi^b ; S. Fadaie^b ; H. Rafii-Tabar^b ; ^c ; ^{rafii-tabar@nano.ipm.ac.ir}
• 关键词：F0-ATPase dynamics ; Stochastic dynamics ; External electric field ; Bio-heat equation
• 刊名：Physica Medica
• 出版年：2012
• 期刊代码：256_11201797
• 类别：med
• 出版时间：July, 2012
• 卷：28
• 期：3
• 页码：221-229
• 文件大小：660 K

摘要

We model the dynamics of the F₀ component of the F₀F₁-ATPase mitochondrion-based nano-motor operating in a stochastically-fluctuating medium that represents the intracellular environment. The stochastic dynamics are modeled via Langevin equation of motion wherein fluctuations are treated as white noise. We have investigated the influence of an applied alternating electric field on the rotary motion of the F₀ rotor in such an environment. The exposure to the field induces a temperature rise in the mitochondrion鈥檚 membrane, within which the F₀ is embedded. The external field also induces an electric potential that promotes a change in the mitochondrion鈥檚 transmembrane potential (TMP). Both the induced temperature and the change in TMP contribute to a change in the dynamics of the F₀. We have found that for external fields in the radio frequency (RF) range, normally present in the environment and encountered by biological systems, the contribution of the induced thermal effects, relative to that of the induced TMP, to the dynamics of the F₀ is more significant. The changes in the dynamics of the F₀ part affect the frequency of the rotary motion of the F₀F₁-ATPase protein motor which, in turn, affects the production rate of the ATP molecules.