• 作者：J.-C. Pont^a ; C. Patrat^a ; P. Fauque^a ; M.-L. Camp^a ; V. Gayet^b ; J.-P. Wolf^a ; ^{jean-philippe.wolf@cch.aphp.fr}
• 关键词：Reprotoxicit&eacute ; Contrô ; le qualit&eacute ; Ins&eacute ; mination intra-ut&eacute ; rine ; Cath&eacute ; ters ; Poly&eacute ; thylè ; ne
• 刊名：Gynecology Obstetrique & Fertilite
• 出版年：2012
• 期刊代码：108_12979589
• 类别：med
• 出版时间：June, 2012
• 卷：40
• 期：6
• 页码：356-359
• 文件大小：241 K

Objective

To analyze the effectiveness of pre-washing the intrauterine insemination catheters on IUI outcome.

Patients and methods

Infertile couples (n = 322) involved in a IUI program were included in the study. IUI indications were cervical factors, ovulation dysfunction, cryopreserved semen and unexplained infertility. Every other week for two years, IUI catheters were washed with culture medium prior to intrauterine sperm insemination.

Result(s)

Only the first IUI for each couple were analyzed. Washing the catheter, prior to use, resulted in a 49.7%increase in clinical pregnancy rate (22.0%vs 14.7%P < 0.05). This result is observed with fresh sperm (15.7%vs 11.1%) and frozen-thawed sperm as well (31.1%vs 19.8%). The early pregnancy termination rate was similar in all groups.

Discussion and conclusion

Pre-washing the catheter before IUI should be recommended in Good Laboratory Practice Guidelines as it is already the case for embryo transfer catheters. This raises the problem of washing all single-use devices, in contact with gametes or embryos during IVF.