Peripherally inserted central catheter (PICC) is a new device in France, at least for home parenteral nutrition (HPN). As a central intravenous line entering the organism via a peripheral vein of the arm, it offers some advantages on classic tunneled catheter: mainly reduced risk of mechanical or anatomical complications during insertion. Infection rate is identical but thrombosis risk is higher. PICC is appropriate for short or medium duration HPN (less 6 months), particularly in case of contra-indication to large vein puncture.